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Issue 14, 2017
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Palladium-catalyzed aerobic (1+2) annulation of Csp3–H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene

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Abstract

A novel palladium-catalyzed aerobic (1+2) annulation was developed for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene. The palladation of Csp3–H bonds took place twice at the same position in the whole reaction process. Preliminary mechanistic studies by in situ IR revealed that the second C–H palladation and reductive elimination might be slow steps.

Graphical abstract: Palladium-catalyzed aerobic (1+2) annulation of Csp3–H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene

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Article information


Submitted
22 Nov 2016
Accepted
23 Jan 2017
First published
23 Jan 2017

Chem. Commun., 2017,53, 2294-2297
Article type
Communication

Palladium-catalyzed aerobic (1+2) annulation of Csp3–H bonds with olefin for the synthesis of 3-azabicyclo[3.1.0]hex-2-ene

K. Wu, L. Meng, M. Huai, Z. Huang, C. Liu, X. Qi and A. Lei, Chem. Commun., 2017, 53, 2294
DOI: 10.1039/C6CC09332A

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