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Issue 4, 2017
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Biological and related applications of pillar[n]arenes

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Pillar[n]arenes are a new class of synthetic supramolecular macrocycles streamlined by their particular pillar-shaped architecture which consists of an electron-rich cavity and two fine-tuneable rims. The ease and diversity of the functionalization of the two rims open possibilities for the design of new architectures, topological isomers, and scaffolds. Significantly, this emerging class of macrocyclic receptors offers a unique platform for biological purposes. This review article covers the most recent contributions from the pillar[n]arene field in terms of artificial membrane transport systems, controlled drug delivery systems, biomedical imaging, biosensors, cell adhesion, fluorescent sensing, and pesticide detection based on host–guest interactions. The review also uniquely describes the properties of sub-units that make pillar[n]arenes suitable for biological applications and it provides a detailed outline for the design of new innovative pillar-like structures with specific properties to open up a new avenue for pillar[n]arene chemistry.

Graphical abstract: Biological and related applications of pillar[n]arenes

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Publication details

The article was received on 10 Nov 2016, accepted on 28 Nov 2016 and first published on 30 Nov 2016

Article type: Feature Article
DOI: 10.1039/C6CC08967D
Citation: Chem. Commun., 2017,53, 677-696
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    Biological and related applications of pillar[n]arenes

    C. Sathiyajith, R. R. Shaikh, Q. Han, Y. Zhang, K. Meguellati and Y. Yang, Chem. Commun., 2017, 53, 677
    DOI: 10.1039/C6CC08967D

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