Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications

J. Han; A. Schmidt; T. Zhang; H. Permentier; G. M. M. Groothuis; R. Bischoff; F. E. Kühn; P. Horvatovich; A. Casini

doi:10.1039/C6CC08937B

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Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications†

J. Han,^ac A. Schmidt,^b T. Zhang,^a H. Permentier,^a G. M. M. Groothuis,^c R. Bischoff,^a F. E. Kühn,

^b P. Horvatovich*^a and A. Casini

*^cd

Author affiliations

* Corresponding authors

^a Department of Analytical Biochemistry, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
E-mail: p.l.horvatovich@rug.nl

^b Molecular Catalysis, Catalysis Research Center and Department of Chemistry, Technische Universität München, Lichtenbergstr. 4, 85747 Garching bei München, Germany

^c Dept. Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands

^d School of Chemistry, Cardiff University, Park Place, CF103AT Cardiff, UK
E-mail: casinia@cardiff.ac.uk

Abstract

Supramolecular Pd₂L₄ cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd₂L₄ cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.

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Article information

DOI: https://doi.org/10.1039/C6CC08937B
Article type: Communication
Submitted: 09 Nov 2016
Accepted: 03 Jan 2017
First published: 05 Jan 2017

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Chem. Commun., 2017,53, 1405-1408

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Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications

J. Han, A. Schmidt, T. Zhang, H. Permentier, G. M. M. Groothuis, R. Bischoff, F. E. Kühn, P. Horvatovich and A. Casini, Chem. Commun., 2017, 53, 1405 DOI: 10.1039/C6CC08937B

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Chemical Communications

Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications†

Abstract

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Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications

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