Issue 1, 2017
From the journal:

Chemical Communications

Clearing the undergrowth: detection and quantification of low level impurities using 19F NMR†

Pinelopi Moutzouri,a   Peter Kiraly,a   Andrew R. Phillips,b   Steven R. Coombes,c   Mathias Nilssona  and  Gareth A. Morris ORCID logo *a  

* Corresponding authors

a School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
E-mail: g.a.morris@manchester.ac.uk

b Pharmaceutical Sciences, AstraZeneca, Silk Road Business Park, Macclesfield, UK

c Pharmaceutical Technology and Development, AstraZeneca, Silk Road Business Park, Macclesfield, UK

Abstract

A new method for the analysis of low level impurities in sparsely fluorinated species allows measurement of clean high dynamic range 19F spectra, fully decoupled and free of interfering signals from 13C isotopomers.

Graphical abstract: Clearing the undergrowth: detection and quantification of low level impurities using 19F NMR

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6CC08836H
Article type
Communication
Submitted
04 Nov 2016
Accepted
23 Nov 2016
First published
23 Nov 2016
This article is Open Access
Creative Commons BY license

Chem. Commun., 2017,53, 123-125

Permissions

Request permissions

Clearing the undergrowth: detection and quantification of low level impurities using 19F NMR

P. Moutzouri, P. Kiraly, A. R. Phillips, S. R. Coombes, M. Nilsson and G. A. Morris, Chem. Commun., 2017, 53, 123 DOI: 10.1039/C6CC08836H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements