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Issue 10, 2017
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Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

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Abstract

Neuronal accumulation of tau aggregates is a pathological hallmark in multiple neurodegenerative disorders, collectively called tauopathies. A tau aggregation sensor that can monitor abnormal tau aggregation in neurons would facilitate the study of tau aggregation processes and the discovery of tau aggregation blockers. Here, we describe a BODIPY-fluorescence sensor (BD-tau) that selectively responds to pathological tau aggregates in live cells.

Graphical abstract: Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

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Article information


Submitted
04 Nov 2016
Accepted
05 Jan 2017
First published
05 Jan 2017

Chem. Commun., 2017,53, 1607-1610
Article type
Communication

Development of a BODIPY-based fluorescent probe for imaging pathological tau aggregates in live cells

S. Lim, Md. M. Haque, D. Su, D. Kim, J. Lee, Y. Chang and Y. K. Kim, Chem. Commun., 2017, 53, 1607
DOI: 10.1039/C6CC08826K

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