Issue 9, 2017

A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells

Abstract

A new fluorescence-forming probe, coumOCT, designed by fusing cyclooctyne with a coumarin fluorophore was successfully used for the imaging of azido-glycoconjugates in living HeLa cells. This probe is cell-permeable and generates fluorescence after triazole formation, thus minimizing the background signal and enabling the real-time intracellular imaging of glycoconjugate trafficking.

Graphical abstract: A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells

Supplementary files

Article information

Article type
Communication
Submitted
03 Nov 2016
Accepted
22 Dec 2016
First published
22 Dec 2016

Chem. Commun., 2017,53, 1490-1493

A cell-permeable and triazole-forming fluorescent probe for glycoconjugate imaging in live cells

J. Shie, Y. Liu, J. Hsiao, J. Fang and C. Wong, Chem. Commun., 2017, 53, 1490 DOI: 10.1039/C6CC08805H

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