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Issue 1, 2017
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Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

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Abstract

A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.

Graphical abstract: Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

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Publication details

The article was received on 29 Sep 2016, accepted on 18 Nov 2016 and first published on 05 Dec 2016


Article type: Communication
DOI: 10.1039/C6CC07913J
Citation: Chem. Commun., 2017,53, 126-129

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    Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

    G. Yuan, F. Wang, N. A. Stephenson, L. Wang, B. H. Rotstein, N. Vasdev, P. Tang and S. H. Liang, Chem. Commun., 2017, 53, 126
    DOI: 10.1039/C6CC07913J

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