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Issue 9, 2017
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One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(II)-catalyzed cascade C(sp3)–H activations

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Abstract

A novel approach toward quaternary carbon centered cyclobutanes through Pd(II)-catalyzed sequential intramolecular methylene C–H alkylation and intermolecular methine C–H bond arylation, alkenylation, alkylation, alkynylation, allylation, benzylation or alkoxylation is described. These quaternary carbon centered cyclobutanes could be further diversified through Pd(II)-catalyzed γ-C(sp3)–H bond activations. The synthetic utility of this novel approach was exemplified by its application to the synthesis of a bioactive small molecule.

Graphical abstract: One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(ii)-catalyzed cascade C(sp3)–H activations

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Publication details

The article was received on 23 Aug 2016, accepted on 19 Dec 2016 and first published on 04 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC06897A
Citation: Chem. Commun., 2017,53, 1534-1537

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    One-pot synthesis of quaternary carbon centered cyclobutanes via Pd(II)-catalyzed cascade C(sp3)–H activations

    X. Yang, G. Shan, Z. Yang, G. Huang, G. Dong, C. Sheng and Y. Rao, Chem. Commun., 2017, 53, 1534
    DOI: 10.1039/C6CC06897A

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