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Issue 99, 2016
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Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

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Abstract

Aj_EasH is a non-heme iron- and α-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 Å resolution) reported here provides insight into the mechanism of this unusual and complex reaction.

Graphical abstract: Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

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Article information


Submitted
19 Oct 2016
Accepted
22 Nov 2016
First published
22 Nov 2016

This article is Open Access

Chem. Commun., 2016,52, 14306-14309
Article type
Communication

Structural characterization of EasH (Aspergillus japonicus) – an oxidase involved in cycloclavine biosynthesis

D. Jakubczyk, L. Caputi, C. E. M. Stevenson, D. M. Lawson and S. E. O'Connor, Chem. Commun., 2016, 52, 14306
DOI: 10.1039/C6CC08438A

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