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Issue 98, 2016
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Organogel-assisted topochemical synthesis of multivalent glyco-polymer for high-affinity lectin binding

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Abstract

An organogelator, 2,4-undeca-diynyl-4′,6′-O-benzylidene-β-D-galactopyranoside, which aligns its diacetylene upon gelation, has been synthesized. UV irradiation of its gel resulted in topochemical polymerization of the gelator forming polydiacetylene (PDA). We have used this gel-state reaction for the synthesis of surface-immobilized multi-valent glycoclusters, which showed 1000-fold enhanced binding, compared to monomers, with various galactose-binding lectins.

Graphical abstract: Organogel-assisted topochemical synthesis of multivalent glyco-polymer for high-affinity lectin binding

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Publication details

The article was received on 03 Oct 2016, accepted on 07 Nov 2016 and first published on 09 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC07993H
Chem. Commun., 2016,52, 14089-14092

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    Organogel-assisted topochemical synthesis of multivalent glyco-polymer for high-affinity lectin binding

    B. P. Krishnan, S. Raghu, S. Mukherjee and K. M. Sureshan, Chem. Commun., 2016, 52, 14089
    DOI: 10.1039/C6CC07993H

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