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Issue 90, 2016
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Protocol for the purification of protected carbohydrates: toward coupling automated synthesis to alternate-pump recycling high-performance liquid chromatography

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Abstract

Given recent advances in automated oligosaccharide synthesis, analytical techniques that can be coupled to a synthetic framework are needed to not just identify but also purify to homogeneity protected carbohydrate compounds at levels of ≥99.5% purity. Herein, an alternate-pump recycling high-performance liquid chromatography (R-HPLC) method has been developed to allow purification of protected carbohydrates at levels of ≥99.5% purity.

Graphical abstract: Protocol for the purification of protected carbohydrates: toward coupling automated synthesis to alternate-pump recycling high-performance liquid chromatography

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Publication details

The article was received on 17 Sep 2016, accepted on 17 Oct 2016 and first published on 24 Oct 2016


Article type: Communication
DOI: 10.1039/C6CC07584C
Citation: Chem. Commun., 2016,52, 13253-13256
  • Open access: Creative Commons BY license
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    Protocol for the purification of protected carbohydrates: toward coupling automated synthesis to alternate-pump recycling high-performance liquid chromatography

    G. Nagy, T. Peng, D. E. K. Kabotso, M. V. Novotny and N. L. B. Pohl, Chem. Commun., 2016, 52, 13253
    DOI: 10.1039/C6CC07584C

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