Issue 82, 2016
From the journal:

Chemical Communications

Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation†

Alessandra Augurusa,‡a   Meera Mehta,‡a   Manuel Perez,a   Jiangtao Zhua  and  Douglas W. Stephan*a  

* Corresponding authors

a Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Ontario M5S 3H6, Canada
E-mail: dstephan@chem.utoronto.ca

Abstract

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.

Graphical abstract: Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

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Article information

DOI
https://doi.org/10.1039/C6CC06914B
Article type
Communication
Submitted
23 Aug 2016
Accepted
13 Sep 2016
First published
13 Sep 2016

Chem. Commun., 2016,52, 12195-12198

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Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

A. Augurusa, M. Mehta, M. Perez, J. Zhu and D. W. Stephan, Chem. Commun., 2016, 52, 12195 DOI: 10.1039/C6CC06914B

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