Issue 90, 2016
From the journal:

Chemical Communications

Visual detection of single-nucleotide polymorphisms and DNA methyltransferase based on cation-exchange of CuS nanoparticles and click chemistry of functionalized gold nanoparticles†

X. R. Zhang,a   Y. Zhang, ORCID logo a   F. T. Chen,a   Y. Lia  and  S. S. Zhang*b  

* Corresponding authors

a Key Laboratory of Sensor Analysis of Tumor Marker, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

b Shandong Province Key Laboratory of Detection Technology for Tumor Makers, College of Chemistry and Chemical Engineering, Linyi University, Linyi 276000, P. R. China
E-mail: shushzhang@126.com

Abstract

A novel biosensor was developed based on the cation-exchange of CuS nanoparticles (NPs) and Cu(I)-based click chemistry of functionalized gold nanoparticles (AuNPs). As a proof-of-principle, novel applications of this method as a versatile biosensor for single-nucleotide polymorphisms (SNPs) and DNA methyltransferase (MTase) were presented.

Graphical abstract: Visual detection of single-nucleotide polymorphisms and DNA methyltransferase based on cation-exchange of CuS nanoparticles and click chemistry of functionalized gold nanoparticles

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Article information

DOI
https://doi.org/10.1039/C6CC06735B
Article type
Communication
Submitted
16 Aug 2016
Accepted
14 Oct 2016
First published
17 Oct 2016

Chem. Commun., 2016,52, 13261-13264

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Visual detection of single-nucleotide polymorphisms and DNA methyltransferase based on cation-exchange of CuS nanoparticles and click chemistry of functionalized gold nanoparticles

X. R. Zhang, Y. Zhang, F. T. Chen, Y. Li and S. S. Zhang, Chem. Commun., 2016, 52, 13261 DOI: 10.1039/C6CC06735B

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