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Issue 79, 2016
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Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres

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Abstract

A combined specific enrichment and highly efficient solid-phase tagging approach is presented for heparin detection using boronic acid-functionalized mesoporous silica nanospheres as extraction sorbents and nanoscale reactors. It exhibits a faster reaction time (only 6 min), higher tagging-product purity and lower applicable sample concentration compared with liquid-phase tagging.

Graphical abstract: Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres

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Publication details

The article was received on 25 Jul 2016, accepted on 25 Aug 2016 and first published on 30 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC06128A
Chem. Commun., 2016,52, 11779-11782

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    Specific enrichment combined with highly efficient solid-phase tagging for the sensitive detection of heparin based on boronic acid-functionalized mesoporous silica nanospheres

    D. Zhu, J. Ye, Y. Hu, H. M. Wen, A. Kang, Y. Tang, J. Chen, C. X. Shan and X. B. Cui, Chem. Commun., 2016, 52, 11779
    DOI: 10.1039/C6CC06128A

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