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Issue 80, 2016
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A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

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Abstract

A squaramide ester derivative of desferrioxamine B (H3DFO) that is compatible with aqueous solvents and does not induce antibody aggregation is used to attach the siderophore to the antibody trastuzumab. The new conjugates were radiolabeled with zirconium-89 to give complexes that are more resistant to ligand exchange when compared to currently used H3DFO derivatives and result in high quality positron emission tomography images in mouse models of HER2 positive breast cancer.

Graphical abstract: A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

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Publication details

The article was received on 20 Jul 2016, accepted on 19 Aug 2016 and first published on 19 Aug 2016


Article type: Communication
DOI: 10.1039/C6CC05961A
Chem. Commun., 2016,52, 11889-11892

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    A desferrioxamine B squaramide ester for the incorporation of zirconium-89 into antibodies

    S. E. Rudd, P. Roselt, C. Cullinane, R. J. Hicks and P. S. Donnelly, Chem. Commun., 2016, 52, 11889
    DOI: 10.1039/C6CC05961A

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