Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates

Pamela T. Wong; Shengzhuang Tang; Jhindan Mukherjee; Kenny Tang; Kristina Gam; Danielle Isham; Claire Murat; Rachel Sun; James R. Baker; Seok Ki Choi

doi:10.1039/C6CC05179K

Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates†

Pamela T. Wong,*^ab Shengzhuang Tang,^ab Jhindan Mukherjee,^ab Kenny Tang,^a Kristina Gam,^a Danielle Isham,^a Claire Murat,^a Rachel Sun,^a James R. Baker, Jr.^ab and Seok Ki Choi*^ab

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^a Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA
E-mail: ptw@umich.edu, skchoi@umich.edu
Fax: +1 734 615-2506
Tel: +1 734 615-2192

^b Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA

Abstract

We report an active delivery mechanism targeted specifically to Gram(−) bacteria based on the photochemical release of photocaged ciprofloxacin carried by a cell wall-targeted dendrimer nanoconjugate.

Chemical Communications

Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates†

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Light-controlled active release of photocaged ciprofloxacin for lipopolysaccharide-targeted drug delivery using dendrimer conjugates

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