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Issue 75, 2016
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Nanoparticle “switch-on” by tetrazine triggering

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Abstract

This work describes how a small-molecule chemical trigger, reacting through the mediatory of an inverse electron demand Diels–Alder reaction, results in enhanced cellular uptake and selective nanoparticle disintegration and cargo liberation, via gross polymeric morphological alterations. The power of these responsive nanoparticles is demonstrated through encapsulation of the anti-cancer agent doxorubicin and its triggered release, allowing controlled cell death in response to a small-molecule chemical trigger.

Graphical abstract: Nanoparticle “switch-on” by tetrazine triggering

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Supplementary files

Article information


Submitted
19 Jun 2016
Accepted
19 Aug 2016
First published
19 Aug 2016

This article is Open Access

Chem. Commun., 2016,52, 11223-11226
Article type
Communication

Nanoparticle “switch-on” by tetrazine triggering

K. Neumann, S. Jain, J. Geng and M. Bradley, Chem. Commun., 2016, 52, 11223
DOI: 10.1039/C6CC05118A

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