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Issue 85, 2016
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Novel tubulin-targeted cell penetrating antimitotic octapeptide

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Abstract

An antimitotic cell penetrating octapeptide containing single Arg amino acid is discovered, which strongly binds with the exchangeable GTP/GDP binding site of tubulin, inhibits tubulin polymerization, reduces kinesin driven microtubule motility, activates apoptotic and mitotic check point proteins, induces apoptotic death and significantly inhibits the multicellular tumor spheroid growth of HeLa cells.

Graphical abstract: Novel tubulin-targeted cell penetrating antimitotic octapeptide

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Article information


Submitted
18 Jun 2016
Accepted
21 Sep 2016
First published
26 Sep 2016

Chem. Commun., 2016,52, 12657-12660
Article type
Communication

Novel tubulin-targeted cell penetrating antimitotic octapeptide

D. Bhunia, S. Mohapatra, P. Kurkute, S. Ghosh, B. Jana, P. Mondal, A. Saha, G. Das and S. Ghosh, Chem. Commun., 2016, 52, 12657
DOI: 10.1039/C6CC05110C

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