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Issue 79, 2016
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Enantioselective oxidative functionalization of the Csp3–H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

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Abstract

Highly chemoselective and enantioselective one-pot reactions involved in the oxidative functionalization of Csp3–H bonds adjacent to nitrogen atoms in N-aryl glycine esters were developed. The method provided rapid access to a variety of highly functionalized β-hydroxyl-α-amino acid derivatives from simple starting materials under mild conditions.

Graphical abstract: Enantioselective oxidative functionalization of the Csp3–H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

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Article information


Submitted
06 Jun 2016
Accepted
05 Sep 2016
First published
07 Sep 2016

Chem. Commun., 2016,52, 11831-11833
Article type
Communication

Enantioselective oxidative functionalization of the Csp3–H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

L. Qiu, X. Guo, Y. Qian, C. Jing, C. Ma, S. Liu and W. Hu, Chem. Commun., 2016, 52, 11831
DOI: 10.1039/C6CC04710F

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