Determining carbon–carbon connectivities in natural abundance organic powders using dipolar couplings

Abstract

We present a solid-state NMR methodology capable of investigating the carbon skeleton of natural abundance organic powders. The methodology is based on the ¹³C–¹³C dipolar coupling interaction and allows carbon–carbon connectivities to be unambiguously established for a wide range of organic solids. This methodology is particularly suitable for disordered solids, such as natural or synthetic macromolecules, which cannot be studied using conventional diffraction or NMR techniques.