Issue 64, 2016

Fluorescent vinblastine probes for live cell imaging

Abstract

Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.

Graphical abstract: Fluorescent vinblastine probes for live cell imaging

Supplementary files

Article information

Article type
Communication
Submitted
16 May 2016
Accepted
14 Jul 2016
First published
14 Jul 2016

Chem. Commun., 2016,52, 9953-9956

Author version available

Fluorescent vinblastine probes for live cell imaging

L. G. Meimetis, R. J. Giedt, H. Mikula, J. C. Carlson, R. H. Kohler, D. B. Pirovich and R. Weissleder, Chem. Commun., 2016, 52, 9953 DOI: 10.1039/C6CC04129A

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