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Issue 67, 2016
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Focusing on probe-modified peptides: a quick and effective method for target identification

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Abstract

A new and efficient method focusing on probe-modified peptides was developed to identify the target protein and modification site of a hit compound or a drug. This method exhibited high click conjugation efficiency and few false-positive results. The modification site further facilitated target validation, biological mechanism study and new indications exploration.

Graphical abstract: Focusing on probe-modified peptides: a quick and effective method for target identification

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Article information


Submitted
13 May 2016
Accepted
13 Jul 2016
First published
13 Jul 2016

Chem. Commun., 2016,52, 10225-10228
Article type
Communication

Focusing on probe-modified peptides: a quick and effective method for target identification

H. Sun, Y. Ren, W. Hou, L. Li, F. Zeng, S. Li, Y. Ma, X. Liu, S. Chen and Z. Zhang, Chem. Commun., 2016, 52, 10225
DOI: 10.1039/C6CC04030F

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