Issue 67, 2016
From the journal:

Chemical Communications

Focusing on probe-modified peptides: a quick and effective method for target identification†

Huan Sun,ab   Yan Ren,b   Weijie Hou,ab   Lin Li,b   Fanqi Zeng,b   Sisi Li,b   Yongfen Ma,b   Xiao Liu,b   She Chenb  and  Zhiyuan Zhang*bc  

* Corresponding authors

a College of Life Sciences, Beijing Normal University, Beijing 100875, China

b National Institute of Biological Sciences (NIBS), Beijing 102206, China
E-mail: zhangzhiyuan@nibs.ac.cn

c Collaborative Innovation Center for Cancer Medicine, Beijing, China

Abstract

A new and efficient method focusing on probe-modified peptides was developed to identify the target protein and modification site of a hit compound or a drug. This method exhibited high click conjugation efficiency and few false-positive results. The modification site further facilitated target validation, biological mechanism study and new indications exploration.

Graphical abstract: Focusing on probe-modified peptides: a quick and effective method for target identification

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Article information

DOI
https://doi.org/10.1039/C6CC04030F
Article type
Communication
Submitted
13 May 2016
Accepted
13 Jul 2016
First published
13 Jul 2016

Chem. Commun., 2016,52, 10225-10228

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Focusing on probe-modified peptides: a quick and effective method for target identification

H. Sun, Y. Ren, W. Hou, L. Li, F. Zeng, S. Li, Y. Ma, X. Liu, S. Chen and Z. Zhang, Chem. Commun., 2016, 52, 10225 DOI: 10.1039/C6CC04030F

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