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Issue 60, 2016
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A novel iridium/acid co-catalyzed transfer hydrogenative C(sp3)–H bond alkylation to access functionalized N-heteroaromatics

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Abstract

A novel iridium/acid co-catalysed transfer hydrogenative coupling strategy, enabling direct alkylation of C(sp3)–H bonds and atom-economic access to alkyl chain-lengthened N-heteroaromatics from six-membered 2-alkyl cyclic amines and aldehydes, has been demonstrated. This work has built an important basis to convert cyclic amines, a class of bulk chemical raw materials, into functionalized products.

Graphical abstract: A novel iridium/acid co-catalyzed transfer hydrogenative C(sp3)–H bond alkylation to access functionalized N-heteroaromatics

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Publication details

The article was received on 12 May 2016, accepted on 24 Jun 2016 and first published on 24 Jun 2016


Article type: Communication
DOI: 10.1039/C6CC03996K
Chem. Commun., 2016,52, 9359-9362

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    A novel iridium/acid co-catalyzed transfer hydrogenative C(sp3)–H bond alkylation to access functionalized N-heteroaromatics

    Z. Tan, H. Jiang and M. Zhang, Chem. Commun., 2016, 52, 9359
    DOI: 10.1039/C6CC03996K

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