Endocrine-specific NIR fluorophores for adrenal gland targeting

Yoshitomo Ashitate; Andrew Levitz; Min Ho Park; Hoon Hyun; Vivek Venugopal; GwangLi Park; Georges El Fakhri; Maged Henary; Sylvain Gioux; John V. Frangioni; Hak Soo Choi

doi:10.1039/C6CC03845J

Endocrine-specific NIR fluorophores for adrenal gland targeting†

Yoshitomo Ashitate,‡^ab Andrew Levitz,‡^c Min Ho Park,‡^ad Hoon Hyun,^ae Vivek Venugopal,^a GwangLi Park,^af Georges El Fakhri,^f Maged Henary,*^c Sylvain Gioux,^ag John V. Frangioni^ah and Hak Soo Choi*^af

Author affiliations

* Corresponding authors

^a Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA

^b Department of Gastroenterological Surgery II, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

^c Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA
E-mail: mhenary1@gsu.edu
Fax: +1 404-413-5505
Tel: +1 404-413-5566

^d Department of Surgery, Chonnam National University Medical School, Gwangju 501-746, South Korea

^e Department of Biomedical Sciences, Chonnam National University Medical School, Gwangju 501-746, South Korea

^f Gordon Center for Medical Imaging, Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
E-mail: hchoi12@mgh.harvard.edu
Fax: +1 617-643-2604
Tel: +1 617-726-5784

^g ICube Laboratory, University of Strasbourg, Illkirch cedex 67412, France

^h Curadel, LLC, 377 Plantation Street, Worcester, MA 01605, USA

Abstract

The adrenal glands (AGs) are relatively small yet require definitive identification during their resection, or more commonly their avoidance. To enable image-guided surgery involving the AGs, we have developed novel near-infrared (NIR) fluorophores that target the AGs after a single intravenous injection, which provided dual-NIR image-guided resection or avoidance of the AGs during both open and minimally-invasive surgery.

Chemical Communications

Endocrine-specific NIR fluorophores for adrenal gland targeting†

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Endocrine-specific NIR fluorophores for adrenal gland targeting

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