A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein

Tianhai Ji; Dan Liu; Fang Liu; Jiuxing Li; Qingyu Ruan; Yanling Song; Tian Tian; Zhi Zhu; Leiji Zhou; Hui Lin; Chaoyong Yang; Dong Wang

doi:10.1039/C6CC03705D

A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein†

Tianhai Ji,‡^ab Dan Liu,‡^b Fang Liu,^b Jiuxing Li,^b Qingyu Ruan,^b Yanling Song,^b Tian Tian,^b Zhi Zhu,^b Leiji Zhou,^b Hui Lin,*^b Chaoyong Yang^b and Dong Wang*^a

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* Corresponding authors

^a Cancer Center, Daping Hospital and Research Institution of Surgery, Third Military Medical University, Chongqing 400042, P. R. China
E-mail: dongwang64@hotmail.com

^b The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory for Chemical Biology of Fujian Province, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Chenggong Hospital, Xiamen 361005, P. R. China
E-mail: huilin@xmu.edu.cn

Abstract

A portable method for the rapid detection of the disease biomarker C-reactive protein (CRP) with a hand-held pressuremeter was developed. The method allows an ultrasensitive quantitation of CRP within the entire clinical range. The pressure-based method could facilitate CRP measurements in point-of-care testing (POCT) scenarios, such as clinical offices, emergency departments, and community service centers.

Chemical Communications

A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein†

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A pressure-based bioassay for the rapid, portable and quantitative detection of C-reactive protein

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