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Issue 48, 2016
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A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles

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Abstract

The toehold-mediated DNA-strand-displacement reaction has unique programmable properties for driving the catalytic assembly of gold nanoparticles (AuNPs). Herein, we introduced a pH-responsive triplex structure into the DNA-strand-displacement-based catalytic assembly system of DNA–AuNPs to add an additional controlling factor, namely the pH. In this catalytic system, the aggregation rate of AuNPs could be regulated by both internal factors (concentrations of substrate, target, etc.) and an external control (pH gradient). This strategy can be used to construct pH-induced DNA logic gates and sophisticated DNA networks as well as to image instantaneous pH changes in living cells.

Graphical abstract: A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles

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Publication details

The article was received on 13 Apr 2016, accepted on 10 May 2016 and first published on 10 May 2016


Article type: Communication
DOI: 10.1039/C6CC03089K
Citation: Chem. Commun., 2016,52, 7556-7559

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    A pH-responsive DNA nanomachine-controlled catalytic assembly of gold nanoparticles

    D. Yao, H. Li, Y. Guo, X. Zhou, S. Xiao and H. Liang, Chem. Commun., 2016, 52, 7556
    DOI: 10.1039/C6CC03089K

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