Jump to main content
Jump to site search

Issue 62, 2016
Previous Article Next Article

Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines

Author affiliations

Abstract

The first α-sp2-carbon of carbonyl compounds attacked catalytic desymmetrization reaction of aziridines is disclosed. A simple in situ generated magnesium catalyst from 3,3′-bromine-8H-BINOL and dibutylmagnesium was employed. It is interesting that the bromine atom on the chiral ligand plays a key role in introducing a high level of enantioselectivities and high reaction efficiency. Both enantiomers of the ring-opening product could be smoothly obtained by using (R)- and (S)-L7.

Graphical abstract: Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines

Back to tab navigation

Supplementary files

Article information


Submitted
06 Apr 2016
Accepted
14 Jun 2016
First published
14 Jun 2016

Chem. Commun., 2016,52, 9640-9643
Article type
Communication

Simple magnesium catalyst mediated γ-butyrolactams in desymmetrization of meso-aziridines

D. Li, Y. Wang, L. Wang, J. Wang, P. Wang, K. Wang, L. Lin, D. Liu, X. Jiang and D. Yang, Chem. Commun., 2016, 52, 9640
DOI: 10.1039/C6CC02877B

Social activity

Search articles by author

Spotlight

Advertisements