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Issue 48, 2016
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Enantioselective intermolecular cross Rauhut–Currier reactions of activated alkenes with acrolein

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Abstract

The enantioselective intermolecular cross Rauhut–Currier reaction of acrolein with active olefins has been a long-standing challenge because of the competitive MBH reaction and polymerization. Herein a highly enantioselective intermolecular cross Rauhut–Currier reaction of acrolein with 3-acyl acrylates and 2-ene-1,4-diones, which is enabled by newly designed Peng-Phos catalysts. This method is scalable and highly enantioselective (up to 96% ee). Several transformations of the R–C products are carried out to showcase the synthetic utility.

Graphical abstract: Enantioselective intermolecular cross Rauhut–Currier reactions of activated alkenes with acrolein

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Publication details

The article was received on 01 Apr 2016, accepted on 12 May 2016 and first published on 12 May 2016


Article type: Communication
DOI: 10.1039/C6CC02742C
Citation: Chem. Commun., 2016,52, 7612-7615

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    Enantioselective intermolecular cross Rauhut–Currier reactions of activated alkenes with acrolein

    W. Zhou, P. Chen, M. Tao, X. Su, Q. Zhao and J. Zhang, Chem. Commun., 2016, 52, 7612
    DOI: 10.1039/C6CC02742C

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