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Issue 36, 2016
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A FRET-enabled molecular peptide beacon with a significant red shift for the ratiometric detection of nucleic acids

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Abstract

A cationic molecular peptide beacon NAP1 functionalized with a fluorescence resonance energy transfer-pair at its ends allows the ratiometric detection of ds-DNA with a preference for AT rich sequences. NAP1 most likely binds in a folded form into the minor groove of ds-DNA, which results in a remarkable change in its fluorescence properties. As NAP1 exhibits quite low cytotoxicity, it can also be used for imaging of nuclear DNA in cells.

Graphical abstract: A FRET-enabled molecular peptide beacon with a significant red shift for the ratiometric detection of nucleic acids

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Supplementary files

Article information


Submitted
10 Mar 2016
Accepted
04 Apr 2016
First published
04 Apr 2016

Chem. Commun., 2016,52, 6134-6137
Article type
Communication

A FRET-enabled molecular peptide beacon with a significant red shift for the ratiometric detection of nucleic acids

D. Maity, J. Jiang, M. Ehlers, J. Wu and C. Schmuck, Chem. Commun., 2016, 52, 6134
DOI: 10.1039/C6CC02138G

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