Jump to main content
Jump to site search

Issue 42, 2016
Previous Article Next Article

Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

Author affiliations

Abstract

We here report on the design and synthesis of tailor-made furan-modified peptide nucleic acid (PNA) probes for covalent targeting of single stranded DNA through a crosslinking strategy. After introducing furan-containing building blocks into a PNA sequence, hybridization and furan-oxidation based crosslinking to DNA is investigated. The structure of the crosslinked products is characterized and preliminary investigations concerning the application of these systems to double stranded DNA are shown.

Graphical abstract: Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Mar 2016, accepted on 22 Apr 2016 and first published on 27 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC02062C
Author version
available:
Download author version (PDF)
Chem. Commun., 2016,52, 6930-6933

  •   Request permissions

    Furan-PNA: a mildly inducible irreversible interstrand crosslinking system targeting single and double stranded DNA

    A. Manicardi, E. Gyssels, R. Corradini and A. Madder, Chem. Commun., 2016, 52, 6930
    DOI: 10.1039/C6CC02062C

Search articles by author

Spotlight

Advertisements