Issue 36, 2016

Novel chemoselective 18F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions

Abstract

We report a novel prosthetic group based on a heterocyclic methylsulfone derivative for the rapid, stable, and chemoselective 18F-labeling of thiol-containing (bio)molecules under mild aqueous reaction conditions. Compared to established maleimide approaches, the new methodology displays some clear advantages for imaging probe development.

Graphical abstract: Novel chemoselective 18F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2016
Accepted
30 Mar 2016
First published
30 Mar 2016

Chem. Commun., 2016,52, 6083-6086

Author version available

Novel chemoselective 18F-radiolabeling of thiol-containing biomolecules under mild aqueous conditions

A. Chiotellis, F. Sladojevich, L. Mu, A. Müller Herde, I. E. Valverde, V. Tolmachev, R. Schibli, S. M. Ametamey and T. L. Mindt, Chem. Commun., 2016, 52, 6083 DOI: 10.1039/C6CC01982J

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