Issue 46, 2016

A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

Abstract

A C2 symmetric small molecule composed of L-phenylalanine and isophthalamide was found to function as a Cl/HCO3 dual transporter and self-assemble into chloride channels. In Ussing-chamber based short-circuit current measurements, this molecule elicited chloride-dependent short-circuit current (Isc) increase in both Calu-3 cell and CFBE41o-cell (with F508del mutant CFTR) monolayers.

Graphical abstract: A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

Supplementary files

Article information

Article type
Communication
Submitted
05 Mar 2016
Accepted
03 May 2016
First published
18 May 2016

Chem. Commun., 2016,52, 7380-7383

A small synthetic molecule functions as a chloride–bicarbonate dual-transporter and induces chloride secretion in cells

P. Liu, S. Li, F. Shen, W. Ko, X. Yao and D. Yang, Chem. Commun., 2016, 52, 7380 DOI: 10.1039/C6CC01964A

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