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Issue 48, 2016
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Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs

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Abstract

A microtubule targeted peptide-based delivery vehicle has been designed using two oppositely charged peptides, which targets tubulin/microtubules, delivers both hydrophilic and hydrophobic drugs into their target site through lysosome at acidic pH. Drug loaded vesicles show a significant anticancer effect compared to control drugs in a 2D monolayer and a 3D spheroid cell.

Graphical abstract: Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs

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Publication details

The article was received on 27 Feb 2016, accepted on 22 Apr 2016 and first published on 26 Apr 2016


Article type: Communication
DOI: 10.1039/C6CC01769J
Citation: Chem. Commun., 2016,52, 7549-7552

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    Design of a novel microtubule targeted peptide vesicle for delivering different anticancer drugs

    A. Adak, S. Mohapatra, P. Mondal, B. Jana and S. Ghosh, Chem. Commun., 2016, 52, 7549
    DOI: 10.1039/C6CC01769J

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