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Issue 33, 2016
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Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

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Abstract

One switchable affinity peptide, STP, is screened out from a high-throughput library by an integrated imprinting microarray. STP is pH triggered and also the ligand of the marker VEGFR2. Efficient cell recognition and penetration as well as an in vivo image could be “turned on” and accelerated only in the condition of VEGFR2 overexpression and a mild acidic environment.

Graphical abstract: Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

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Publication details

The article was received on 13 Feb 2016, accepted on 22 Mar 2016 and first published on 22 Mar 2016


Article type: Communication
DOI: 10.1039/C6CC01302C
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Citation: Chem. Commun., 2016,52, 5690-5693

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    Switchable probes: pH-triggered and VEGFR2 targeted peptides screening through imprinting microarray

    Y. Qian, W. Wang, Z. Wang, Q. Han, X. Jia, S. Yang and Z. Hu, Chem. Commun., 2016, 52, 5690
    DOI: 10.1039/C6CC01302C

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