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Issue 31, 2016
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Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines

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Abstract

A copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes was described. The reaction worked well for both aliphatic and aromatic aldehydes and produced not only the direct oxidative coupling ketones but also cyclic hydroxamic esters derived from quinazolines.

Graphical abstract: Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines

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Article information


Submitted
02 Feb 2016
Accepted
29 Feb 2016
First published
07 Mar 2016

Chem. Commun., 2016,52, 5375-5378
Article type
Communication

Copper-catalyzed oxidative coupling between quinazoline 3-oxides and unactivated aldehydes: an efficient approach to functionalized quinazolines

L. Fan, T. Wang, Y. Tian, F. Xiong, S. Wu, Q. Liang and J. Zhao, Chem. Commun., 2016, 52, 5375
DOI: 10.1039/C6CC00946H

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