Issue 21, 2016
From the journal:

Chemical Communications

Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation†

D. Katayev,a   J. Václavík,ab   F. Brüning,a   B. Commarea  and  A. Togni ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, Vladimir-Prelog-Weg 2, 8093 Zürich, Switzerland
E-mail: atogni@ethz.ch

b Institute of Organic Chemistry and Biochemistry, v.v.i. Academy of Sciences of the Czech Republic, Flemingovo nám. 2, 166 10 Prague, Czech Republic

Abstract

Efficient protocols enabling the rapid installation of trifluoromethyl, as well as further functionalized fluoroalkyl groups by an electrophilic perfluoroalkylation of lactam-derived ketene silyl amides (KSAs) using hypervalent iodine reagents 1 and 2 have been developed.

Graphical abstract: Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

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Article information

DOI
https://doi.org/10.1039/C6CC00700G
Article type
Communication
Submitted
24 Jan 2016
Accepted
12 Feb 2016
First published
12 Feb 2016

Chem. Commun., 2016,52, 4049-4052

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Synthesis of quaternary α-perfluoroalkyl lactams via electrophilic perfluoroalkylation

D. Katayev, J. Václavík, F. Brüning, B. Commare and A. Togni, Chem. Commun., 2016, 52, 4049 DOI: 10.1039/C6CC00700G

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