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Issue 30, 2016
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Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate

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Abstract

Structural and thermal data were obtained for a novel hemihydrate of 6-mercaptopurine. The hemihydrate shows increased solubility and bioavailability when compared to the monohydrate form, better stability against conversion in aqueous media than the anhydrate form, and a dehydration temperature of 240 °C, the highest of any known hydrate crystal.

Graphical abstract: Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate

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Supplementary files

Article information


Submitted
15 Jan 2016
Accepted
10 Mar 2016
First published
11 Mar 2016

Chem. Commun., 2016,52, 5281-5284
Article type
Communication
Author version available

Improved pharmacokinetics of mercaptopurine afforded by a thermally robust hemihydrate

K. M. Kersten and A. J. Matzger, Chem. Commun., 2016, 52, 5281
DOI: 10.1039/C6CC00424E

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