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Issue 22, 2016
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Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host–guest chemistry

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Abstract

The combination of potent chemical moieties with biologically active proteins is key to some of today's most innovative therapeutic drugs. In order to obviate any chemical modification of the proteins, we present a novel and powerful strategy for the selective conjugation of recombinant protein domains with synthetically derived peptides via a cucurbit[8]uril host–guest chemistry approach.

Graphical abstract: Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host–guest chemistry

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Publication details

The article was received on 15 Jan 2016, accepted on 19 Feb 2016 and first published on 22 Feb 2016


Article type: Communication
DOI: 10.1039/C6CC00405A
Chem. Commun., 2016,52, 4235-4238
  • Open access: Creative Commons BY license
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    Selective, non-covalent conjugation of synthetic peptides with recombinant proteins mediated by host–guest chemistry

    R. J. Gubeli, S. Sonzini, A. Podmore, P. Ravn, O. A. Scherman and C. F. van der Walle, Chem. Commun., 2016, 52, 4235
    DOI: 10.1039/C6CC00405A

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