Issue 21, 2016
From the journal:

Chemical Communications

A peptide hydrogel derived from a fragment of human cardiac troponin C†

Luis M. De Leon-Rodriguez,*a   Meder Kamalov,b   Yacine Hemar,b   Alok K. Mitra,a   Valeria Castelletto,c   Daniel Hermida-Merino,d   Ian W. Hamleyc  and  Margaret A. Brimble*a  

* Corresponding authors

a School of Biological Sciences, The University of Auckland, 3 Symonds St, Auckland, New Zealand
E-mail: l.deleon@auckland.ac.nz, m.brimble@auckland.ac.nz

b School of Chemical Sciences, The University of Auckland, 23 Symonds St, Auckland, New Zealand

c School of Chemistry, Food Science and Pharmacy, University of Reading, Whiteknights, Reading, UK

d European Synchrotron Radiation Laboratory (ESRF), Grenoble, France

Abstract

The human cardiac troponin C peptide fragment H-V9EQLTEEQKNEFKAAFDIFVLGA31-OH, which covers helix-A in the native protein, self-assembles into β-sheet fibrils in solution. These fibrils further entangle to give a hydrogel. This peptide may therefore serve as a template for development of novel biomaterials.

Graphical abstract: A peptide hydrogel derived from a fragment of human cardiac troponin C

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Article information

DOI
https://doi.org/10.1039/C6CC00209A
Article type
Communication
Submitted
09 Jan 2016
Accepted
12 Feb 2016
First published
12 Feb 2016

Chem. Commun., 2016,52, 4056-4059

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A peptide hydrogel derived from a fragment of human cardiac troponin C

L. M. De Leon-Rodriguez, M. Kamalov, Y. Hemar, A. K. Mitra, V. Castelletto, D. Hermida-Merino, I. W. Hamley and M. A. Brimble, Chem. Commun., 2016, 52, 4056 DOI: 10.1039/C6CC00209A

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