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Issue 19, 2016

Cascade DNA logic device programmed ratiometric DNA analysis and logic devices based on a fluorescent dual-signal probe of a G-quadruplex DNAzyme

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Abstract

Herein, two fluorescence sensitive substrates of G-quadruplex/hemin DNAzyme with inverse responses (Scopoletin and Amplex Red) were simultaneously used in one homogeneous system to construct a cascade advanced DNA logic device for the first time (a functional logic device (a three input based DNA calliper) cascade with an advanced non-arithmetic logic gate (1 to 2 decoder)). This cascade logic device was applied to label-free ratiometric target DNA detection and length measurement.

Graphical abstract: Cascade DNA logic device programmed ratiometric DNA analysis and logic devices based on a fluorescent dual-signal probe of a G-quadruplex DNAzyme

Supplementary files

Article information


Submitted
25 Dec 2015
Accepted
03 Feb 2016
First published
03 Feb 2016

Chem. Commun., 2016,52, 3766-3769
Article type
Communication

Cascade DNA logic device programmed ratiometric DNA analysis and logic devices based on a fluorescent dual-signal probe of a G-quadruplex DNAzyme

D. Fan, J. Zhu, Q. Zhai, E. Wang and S. Dong, Chem. Commun., 2016, 52, 3766 DOI: 10.1039/C5CC10556K

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