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Issue 24, 2016
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Aerobic oxidative cyclization of benzamides via meta-selective C–H tert-alkylation: rapid entry to 7-alkylated isoquinolinediones

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Abstract

A novel copper-catalyzed aerobic oxidative cyclization of benzamides via meta-selective C–H tert-alkylation using AIBN and analogues as radical precursors was described. This strategy provides an elusive and rapid means to 7-tert-alkylated isoquinolinediones, as well as the construction of tertiary alkyl–aryl C(sp3)–C(sp2) bonds with positional selectivity.

Graphical abstract: Aerobic oxidative cyclization of benzamides via meta-selective C–H tert-alkylation: rapid entry to 7-alkylated isoquinolinediones

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Supplementary files

Article information


Submitted
21 Dec 2015
Accepted
10 Feb 2016
First published
10 Feb 2016

Chem. Commun., 2016,52, 4470-4473
Article type
Communication
Author version available

Aerobic oxidative cyclization of benzamides via meta-selective C–H tert-alkylation: rapid entry to 7-alkylated isoquinolinediones

S. Tang, Y. Deng, J. Li, W. Wang, Y. Wang, Z. Li, L. Yuan, S. Chen and R. Sheng, Chem. Commun., 2016, 52, 4470
DOI: 10.1039/C5CC10464E

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