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Issue 25, 2016
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Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling

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Abstract

The photo-induced reactions of diaryltetrazoles with carboxylic acids in aqueous solution were investigated. Besides measuring the apparent second-order rate constant and evaluating the functional group compatibility of these reactions, we further incorporated the tetrazoles into SAHA, leading to a new active-site-directed probe for labelling HDACs in both cell lysates and living cells.

Graphical abstract: Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling

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Supplementary files

Article information


Submitted
21 Dec 2015
Accepted
01 Mar 2016
First published
02 Mar 2016

Chem. Commun., 2016,52, 4702-4705
Article type
Communication

Photo-induced coupling reactions of tetrazoles with carboxylic acids in aqueous solution: application in protein labelling

S. Zhao, J. Dai, M. Hu, C. Liu, R. Meng, X. Liu, C. Wang and T. Luo, Chem. Commun., 2016, 52, 4702
DOI: 10.1039/C5CC10445A

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