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Issue 25, 2016
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Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers

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Abstract

Membrane-active agents represent a promising alternative to overcome antibiotic resistance. Here, we report cationic-amphiphilic polymers with variations in the side chain architecture such as cyclization, isomerization and unsaturation that resulted in potent antibacterial activity and low mammalian cell toxicity with a membrane-active mode of action.

Graphical abstract: Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers

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Supplementary files

Article information


Submitted
02 Dec 2015
Accepted
27 Feb 2016
First published
01 Mar 2016

Chem. Commun., 2016,52, 4644-4647
Article type
Communication
Author version available

Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers

D. S. S. M. Uppu, M. Bhowmik, S. Samaddar and J. Haldar, Chem. Commun., 2016, 52, 4644
DOI: 10.1039/C5CC09930G

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