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Issue 9, 2016
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Label-free ultrasensitive detection of telomerase activity via multiple telomeric hemin/G-quadruplex triggered polyaniline deposition and a DNA tetrahedron-structure regulated signal

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Abstract

Label-free detection of telomerase activity was done by using telomeric hemin/G-quadruplex triggered polyaniline deposition, not only on themselves but also on the DNA tetrahedron-structure (DTS). DTS size has a great impact on telomerase accessibility, reactivity and detection sensitivity. The method has been used to evaluate bladder cancer development.

Graphical abstract: Label-free ultrasensitive detection of telomerase activity via multiple telomeric hemin/G-quadruplex triggered polyaniline deposition and a DNA tetrahedron-structure regulated signal

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Publication details

The article was received on 27 Nov 2015, accepted on 11 Dec 2015 and first published on 11 Dec 2015


Article type: Communication
DOI: 10.1039/C5CC09800A
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Chem. Commun., 2016,52, 1796-1799

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    Label-free ultrasensitive detection of telomerase activity via multiple telomeric hemin/G-quadruplex triggered polyaniline deposition and a DNA tetrahedron-structure regulated signal

    Y. Liu, M. Wei, X. Liu, W. Wei, H. Zhao, Y. Zhang and S. Liu, Chem. Commun., 2016, 52, 1796
    DOI: 10.1039/C5CC09800A

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