Issue 11, 2016
From the journal:

Chemical Communications

Hyperpolarised organic phosphates as NMR reporters of compartmental pH†

Pernille Rose Jensenab  and  Sebastian Meier*c  

* Corresponding authors

a Technical University of Denmark, Department of Electrical Engineering, Ørsteds Plads, Building 348, DK-2800 Kgs. Lyngby, Denmark

b Albeda Research, Ole Maaløvs Vej 3, DK-2200 Copenhagen, Denmark

c Technical University of Denmark, Department of Chemistry, Kemitorvet, Building 207, DK-2800 Kgs. Lyngby, Denmark
E-mail: semei@kemi.dtu.dk

Abstract

Organic phosphate metabolites contain functional groups with pKa values near the physiologic pH range, yielding pH-dependent 13C chemical shift changes of adjacent quaternary carbon sites. When formed in defined cellular compartments from exogenous hyperpolarised 13C substrates, metabolites can thus yield localised pH values and correlations of organelle pH and catalytic activity.

Graphical abstract: Hyperpolarised organic phosphates as NMR reporters of compartmental pH

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C5CC09790H
Article type
Communication
Submitted
26 Nov 2015
Accepted
17 Dec 2015
First published
17 Dec 2015

Chem. Commun., 2016,52, 2288-2291

Author version available

Download author version (PDF)

Permissions

Request permissions

Hyperpolarised organic phosphates as NMR reporters of compartmental pH

P. R. Jensen and S. Meier, Chem. Commun., 2016, 52, 2288 DOI: 10.1039/C5CC09790H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements