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Issue 15, 2016
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Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores

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Abstract

Gold-catalyzed [2+2+2]-cycloadditions of two discrete ynamides and one nitrile afford 2,4-diaminopyridine derivatives that are not readily prepared from typical low-valent-metal catalysts. Our mechanistic analysis reveals that the reaction chemoselectivity is controlled by the types of sulfonamides of ynamides.

Graphical abstract: Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores

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Publication details

The article was received on 23 Nov 2015, accepted on 15 Jan 2016 and first published on 15 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC09688J
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Citation: Chem. Commun., 2016,52, 3187-3190

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    Sulfonamide-directed gold-catalyzed [2+2+2]-cycloadditions of nitriles with two discrete ynamides to construct 2,4-diaminopyridine cores

    Y. Chen, P. Sharma and R. Liu, Chem. Commun., 2016, 52, 3187
    DOI: 10.1039/C5CC09688J

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