Issue 10, 2016
From the journal:

Chemical Communications

Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone–PhoSL hybrid†

Mai Okuyama,a   Haruna Ueno,a   Yuka Kobayashi,b   Hirokazu Kawagishi,c   Daisuke Takahashia  and  Kazunobu Toshima*a  

* Corresponding authors

a Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan
E-mail: toshima@applc.keio.ac.jp
Fax: +81 45-566-1576

b J-Oil Mills, Inc., Yokohama 245-0064, Japan

c Research Institute of Green Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan

Abstract

A purposefully-designed anthraquinone–Pholiota squarrosa lectin (PhoSL) hybrid effectively degraded α-fetoprotein-L3 (AFP-L3) associated with liver cancer. Degradation was achieved under light irradiation in the absence of any additives and under neutral pH conditions. Moreover, the hybrid effectively exhibited selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells upon photo-irradiation.

Graphical abstract: Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone–PhoSL hybrid

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Article information

DOI
https://doi.org/10.1039/C5CC09542E
Article type
Communication
Submitted
18 Nov 2015
Accepted
14 Dec 2015
First published
14 Dec 2015

Chem. Commun., 2016,52, 2169-2172

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Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone–PhoSL hybrid

M. Okuyama, H. Ueno, Y. Kobayashi, H. Kawagishi, D. Takahashi and K. Toshima, Chem. Commun., 2016, 52, 2169 DOI: 10.1039/C5CC09542E

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