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Issue 10, 2016
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Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone–PhoSL hybrid

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Abstract

A purposefully-designed anthraquinone–Pholiota squarrosa lectin (PhoSL) hybrid effectively degraded α-fetoprotein-L3 (AFP-L3) associated with liver cancer. Degradation was achieved under light irradiation in the absence of any additives and under neutral pH conditions. Moreover, the hybrid effectively exhibited selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells upon photo-irradiation.

Graphical abstract: Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone–PhoSL hybrid

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Supplementary files

Article information


Submitted
18 Nov 2015
Accepted
14 Dec 2015
First published
14 Dec 2015

Chem. Commun., 2016,52, 2169-2172
Article type
Communication
Author version available

Target-selective photo-degradation of AFP-L3 and selective photo-cytotoxicity against HuH-7 hepatocarcinoma cells using an anthraquinone–PhoSL hybrid

M. Okuyama, H. Ueno, Y. Kobayashi, H. Kawagishi, D. Takahashi and K. Toshima, Chem. Commun., 2016, 52, 2169
DOI: 10.1039/C5CC09542E

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