Issue 11, 2016

Nanoparticle delivery of sterically hindered platinum(iv) prodrugs shows 100 times higher potency than that of cisplatin upon light activation

Abstract

The introduction of a sterically hindered pyridine ligand to a photosensitive platinum(IV) drug for drug delivery resulted in a >100 fold increase in effectiveness compared to the gold standard, cisplatin.

Graphical abstract: Nanoparticle delivery of sterically hindered platinum(iv) prodrugs shows 100 times higher potency than that of cisplatin upon light activation

Supplementary files

Article information

Article type
Communication
Submitted
17 Nov 2015
Accepted
03 Dec 2015
First published
07 Dec 2015

Chem. Commun., 2016,52, 2281-2283

Author version available

Nanoparticle delivery of sterically hindered platinum(IV) prodrugs shows 100 times higher potency than that of cisplatin upon light activation

H. Song, X. Kang, J. Sun, X. Jing, Z. Wang, L. Yan, R. Qi and M. Zheng, Chem. Commun., 2016, 52, 2281 DOI: 10.1039/C5CC09534D

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