Jump to main content
Jump to site search

Issue 13, 2016
Previous Article Next Article

A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

Author affiliations

Abstract

A new mitochondria-targeted fluorescent probe HCy-D, constructed by dansyl and hemicyanine fluorophores, for SO2 derivatives (HSO3/SO32−) was presented. This probe was designed based on a new FRET platform. HCy-D showed a ratiometric, sensitive and rapid response to HSO3/SO32−. Importantly, HCy-D was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.

Graphical abstract: A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Nov 2015, accepted on 05 Jan 2016 and first published on 05 Jan 2016


Article type: Communication
DOI: 10.1039/C5CC09092J
Chem. Commun., 2016,52, 2760-2763

  •   Request permissions

    A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells

    D. Li, Z. Wang, X. Cao, J. Cui, X. Wang, H. Cui, J. Miao and B. Zhao, Chem. Commun., 2016, 52, 2760
    DOI: 10.1039/C5CC09092J

Search articles by author

Spotlight

Advertisements