Issue 17, 2016

A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors

Abstract

A novel fluorescent probe for in vitro and in vivo imaging of dipeptidyl peptidase-4 (DPP-4) was designed and synthesized. This probe is successfully utilized to screen DPP-4 inhibitors in living 3T3-L1 cells and zebrafish, which provides a novel approach for the discovery of anti-diabetes drugs.

Graphical abstract: A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors

Supplementary files

Article information

Article type
Communication
Submitted
27 Oct 2015
Accepted
19 Jan 2016
First published
19 Jan 2016

Chem. Commun., 2016,52, 3478-3481

Author version available

A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors

Y. Wang, X. Wu, Y. Cheng and X. Zhao, Chem. Commun., 2016, 52, 3478 DOI: 10.1039/C5CC08921B

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